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Fig. 5 | The Journal of Physiological Sciences

Fig. 5

From: Mechanisms of astrocytic K+ clearance and swelling under high extracellular K+ concentrations

Fig. 5

Simulated drug effects on high [K+]out-induced changes in volume and ion concentration. a Simulated drug effects on high [K+]out-induced changes in volume and intracellular ion concentration. The [K+]out conditions (row 1) in Figs. 3 and 4 were used to simulate high [K+]out-induced changes in volume (row 2) and intracellular ion concentration (row 3) after the blocking of one of the transporters or ion channels. Simulated results are shown separately for 90 % blocks of Na,K-ATPase (column 1), NKCC (column 2), and KIR channels (column 3). Simulation results without blocking are shown as dotted lines, and b the simulated effects of different block levels on volume and intracellular ion concentration. The effects of various block levels were calculated at the end of 30-min sessions; the results are shown for cell volume (row 1) and intracellular ion concentration (row 2)

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