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Table 3 Effects of Zn(ASA)2 post-treatment on hemodynamic parameters and left ventricular cardiac function

From: Administration of zinc complex of acetylsalicylic acid after the onset of myocardial injury protects the heart by upregulation of antioxidant enzymes

 

Control

Iso

Iso + Zn(ASA)2

Zn(ASA)2

Heart rate (beats/min)

407 ± 10

467 ± 13*

453 ± 18

412 ± 7#

Systolic blood pressure (mmHg)

129 ± 10

107 ± 4

104 ± 3*

126 ± 6

Diastolic blood pressure (mmHg)

101 ± 10

86 ± 3

85 ± 2

99 ± 7

Mean arterial pressure (mmHg)

110 ± 10

93 ± 3

91 ± 2

108 ± 7

Ejection fraction (%)

47 ± 7

27 ± 4*

33 ± 9

55 ± 7#

E max (mmHg/µl)

5 ± 1

3 ± 1*

5 ± 1#

4 ± 0

PRSW (mmHg)

77 ± 7

60 ± 6

85 ± 6#

105 ± 6#

Tau-g

9.2 ± 1.0

14.4 ± 0.9*

13.1 ± 0.6*

10.6 ± 0.5#

  1. All values are expressed as mean ± SEM
  2. Iso isoproterenol, Zn(ASA) 2 zinc complex of acetylsalicylic acid, E max the slope of the left-ventricular end-systolic pressure–volume relationship, PRSW preload recruitable stroke work, Tau-g time constant of LV pressure decay
  3. P < 0.05 vs Control; # P < 0.05 vs Iso; $ P < 0.05 vs Iso + Zn(ASA)2