Fig. 3
From: Delayed onset muscle soreness: Involvement of neurotrophic factors
GDNF upregulation in the muscle after LC. a GDNF mRNA of the EDL was upregulated 12 h–1 day after LC. b, c Expression of GDNF mRNA (white arrowheads) in EDL muscle 12 h after LC, shown by use of dark-field photomicrographs of in-situ hybridization histochemistry (oblique sections), was increased on the ipsilateral side (c) compared with the contralateral side (b). Scale bar 100 µm. d Bright-field photomicrograph (longitudinal section) at greater magnification shows in-situ hybridization signals for GDNF mRNA (black arrowhead) in the ipsilateral muscle. Scale bar 10 µm. Note that GDNF mRNA signals are observed around the nuclei of muscle cells and/or satellite cells. Modified from Murase et al. [47]