Fig. 6

Augmentation of antioxidant status by EDHB. a Increased levels of GSH in EDHB-treated groups, indicative of enhanced anti-oxidant status thus helps in protection against hypoxia-induced damage. b GPx inhibits the formation of free radicals by reducing peroxides to water. Elevated levels of GPx in EDHB-treated groups signifies reduced oxidative stress. c A higher level of SOD in EDHB-treated groups indicates a potential defense system against ROS, as SOD provides the first line of defence against oxidative stress. Values are mean ± SD. #Significantly different with respect to normoxia control (p < 0.01), ##significantly different with respect to normoxia control (p < 0.05), *significantly different with respect to hypoxia control (p < 0.01). NC normoxia control, HC hypoxia control, ND1 normoxia EDHB 500 μM, HD1 hypoxia EDHB 500 μM, ND2 normoxia EDHB 1,000 μM, HD2 hypoxia EDHB 1,000 μM