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Fig. 8 | The Journal of Physiological Sciences

Fig. 8

From: Proposed new lymphology combined with lymphatic physiology, innate immunology, and oncology

Fig. 8

Proposed hypothesis of interstitial flow-mediated development of acidic microenvironments in tumor tissues. Proposed hypothesis that shear stress, the mechanical force produced by interstitial fluid flow, in tumor tissues plays a key role in producing an acidic microenvironment for carcinoma cells by the cell surface F1/F0 ATP synthase-activated extracellular secretion of large amounts of ATP and high CO2 gas excretion from the carcinoma cells. Data from Kawai et al. [110], with permission

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