Fig. 3

Comparison of sIPSGs among in vivo, cultured, and acute hippocampal networks. Representative sIPSG traces recorded from three CA1 pyramidal neurons each in in vivo preparations (a), in a slice culture (b), and in an acute slice (c). d The mean, CV, skewness, and kurtosis of the sIPSG fluctuations are calculated for 14 cells of in vivo preparations (red), 24 cells of slice cultures (blue), and 14 cells of acute slices (green). *P < 0.05, **P < 0.01, ***P < 0.001, Mann-Whitney’s U test with Bonferroni correction. Error bars are SDs. e The mean ± SD of sIPSG event frequency. ***P < 0.001, Mann-Whitney’s U test with Bonferroni correction. f The five parameters of individual neurons were dimension reduced to the 2D space using multidimensional scaling (MDS). Each dot indicates a single cell, and its color corresponds to the cohort, in vivo (red), slice culture (blue), and acute slice (green). The data similarity is expressed as the pairwise Euclidean distance. g The MDS results in f are classified in a dendrogram