Fig. 4
From: Luminal trypsin induces enteric nerve-mediated anion secretion in the mouse cecum
Role of enteric submucosal neurons in the 100 μM mucosal trypsin-induced Cl− secretion. Tetrodotoxin (TTX, 300 nM), atropine (10 μM), hexamethonium (10 μM), L-703,606 (10 μM), and pyrilamine (10 μM) were added to the serosal side 20 min before adding trypsin (100 μM) to the mucosal side. The maximum values for the increase in I sc (ΔI sc) induced by trypsin were determined and are expressed as a percentage of the control response obtained in the adjacent tissue. Each data value is presented as the mean ± SE, with n = 4 for L-703,606, and n = 5 for the others. *0.01 < P < 0.05 and **P < 0.01, compared with the control response by using the paired t test