Fig. 1

Changes in the short-circuit current (I _sc) and transmucosal conductance (G _t) induced by mucosal trypsin and the effect of the tetrodotoxin (TTX) pretreatment. a Time-course characteristics of the changes in I _sc and G _t induced by 100 μM trypsin which was added to the mucosal side at the arrowed time in the absence and presence of TTX (300 nM, serosal side). A progressively increasing G _t change was apparent 20–30 min after starting the trypsin treatment with some but not all preparations. Mean values are presented, n = 6. b Concentration dependence of the trypsin-induced changes in I _sc (∆I _sc, peak increases) and G _t (∆G _t, initial increases before the second increase were apparent). Each data value is presented as the mean ± SE, with 5–7 animals being used