Fig. 7
ASIC1a mediates apical HCL stimulating HCO3 − secretion. Time course of HCO3 − secretion by control or omeprazole-exposed Caco-2 monolayers that was apically induced by 10 mM HCL (a). Basal (at 20 min; b, d) and peak acid-stimulated HCO3 − secretion (at 50 min; c, e) by control or omeprazole-exposed Caco-2 monolayers that were pre-treated with 30 nM PcTx1, 50 μM BAPTA-AM, or 50 μM GlyH-101. DMSO 0.3 % (vol/vol) was used as vehicle for preparation of inhibitors. *P < 0.05, **P < 0.01, ***P < 0.001 compared with the corresponding control group. (n = 5)