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Table 2 Concentration-dependent effects of PGE2, ONO-DI-004, or ONO-AE-248 on longitudinal muscle

From: Role of PGE2 in the colonic motility: PGE2 generates and enhances spontaneous contractions of longitudinal smooth muscle in the rat colon

 

Frequencya

Mean amplitudeb

V max (/20 min)

EC50 (M)

R 2

V max (%CCh)

EC50 (M)

V 0 (M)

R 2

PGE2

6.1

1.1 × 10−8

0.98

33.8

5.6 × 10−8

18.8

0.99

ONO-DI-004

2.3

3.2 × 10−7

0.77

26.1

9.7 × 10−7

19.8

0.99

ONO-AE-248

9.1

2.1 × 10−6

0.99

27.7

5.1 × 10−6

16.1

0.96

  1. Values were derived from the Michaelis–Menten plots
  2. V max maximum response, EC 50 50 % effective concentration, V 0 initial minimum value, R 2 relative contribution to the plot fit
  3. aCalculated using Eq. (1)
  4. bCalculated using Eq. (2)
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The Journal of Physiological Sciences

ISSN: 1880-6562

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