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Fig. 6 | The Journal of Physiological Sciences

Fig. 6

From: Inhibitory effects of monoterpenes on human TRPA1 and the structural basis of their activity

Fig. 6

Comparison of the inhibitory effects of borneol, camphor, and 1,8-cineole on the currents of wild-type hTRPA1 (hTRPA1-WT) and hTRPA1 mutants (hTRPA1-S873V/T874L, hTRPA1-Y812A) expressed in HEK293T cells. Inhibitory effects of borneol at three different concentrations (0.03, 0.3, and 1 mM, a), camphor at three different concentrations (0.03, 0.3, and 3 mM, b), or 1,8-cineole at three different concentrations (1, 5, and 10 mM, c) on TRPA1-mediated current at −60 mV in HEK293T cells expressing hTRPA1-WT or TRPA1 mutants hTRPA1-S873V/T874L (a–c) or hTRPA1-Y812A (d–f), in the absence of extracellular Ca2+. Current magnitude in the presence of borneol, camphor, or 1,8-cineole was normalized to the current in the absence of test compounds. (n = 5–8) **P < 0.01

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