Electrophysiological and pharmacological properties of GABAergic cells in the dorsal raphe nucleus

Table 1 Electrophysiological properties of GFP(+), medial GFP(−), and lateral GFP(−) cells in the DRN

	GFP+	m GFP−	l GFP−
Resting membrane potential (mV)	−69.8 ± 0.7 (74)	−76.6 ± 0.9*** (55)	−69.4 ± 1.3^∫∫∫ (18)
Input resistance (MΩ)	756 ± 34^† (74)	638 ± 28* (55)	588 ± 54 (18)
AP threshold (mV)	−38.3 ± 0.5^††† (74)	−34.1 ± 0.5*** (55)	−31.8 ± 1.1 (18)
AP overshoot (mV)	14.1 ± 1.0 (74)	32.7 ± 0.7*** (55)	14.6 ± 1.8^∫∫∫ (18)
AP amplitude (mV)	52.4 ± 1.0^†† (74)	66.8 ± 0.7*** (55)	46.4 ± 1.6^∫∫∫ (18)
fAHP amplitude (mV)	16.0 ± 0.7^††† (70)	17.0 ± 0.7 (37)	22.4 ± 0.9^∫∫∫ (18)
sAHP amplitude (mV)	21.6 ± 0.5 (69)	29.4 ± 0.7*** (55)	24.2 ± 1.3^∫∫∫ (18)
Half-width (ms)	0.70 ± 0.02 (74)	1.35 ± 0.04*** (55)	0.58 ± 0.04^∫∫∫ (18)
Rise time 10–90 % (ms)	0.29 ± 0.01 (74)	0.44 ± 0.01*** (55)	0.25 ± 0.02^∫∫∫ (18)
Decay time 90–10 % (ms)	0.42 ± 0.02 (74)	1.00 ± 0.04*** (55)	0.33 ± 0.03^∫∫∫ (18)

Values indicate mean ± standard error of the mean. The numbers of data are indicated within parentheses. Special symbols (*, ^∫, ^†) indicate statistically significant differences between groups by the multiple-comparison test, the Tukey–Kramer test (*, ^∫, ^† p < 0.05; **, ^∫∫, ^†† p < 0.01; ***, ^∫∫∫, ^††† p < 0.001). *, ^∫, and ^† correspond to GFP(+) different from mGFP(−), mGFP(−) different from lGFP(−), and lGFP(−) different from GFP(+), respectively
GFP(+) GFP positive, GFP(−) GFP negative, mGFP(−) GFP(−) cells in the medial DRN, lGFP(−) GFP(−) cells in the lateral DRN, AP action potential, fAHP fast after hyperpolarization, sAHP slow after hyperpolarization

ISSN: 1880-6562