A new calpain inhibitor protects left ventricular dysfunction induced by mild ischemia-reperfusion in in situ rat hearts

Table 3 Variables of left ventricular mechanics in time control, mI-R, SNJ + mI-R, and SNJ groups

ESPVR	Time control (n = 5)	mI-R (n = 6)	SNJ + mI-R (n = 15)	SNJ (n = 5)
A (mmHg)
Pre	151 ± 25.7	153 ± 22.5	144 ± 25.9	130 ± 4.3
Post	126 ± 24.4	101 ± 23.6^$	135 ± 33.7	131 ± 11.4
B (ml⁻¹)
Pre	36.4 ± 14.5	21.9 ± 8.5	22.7 ± 13.5	21.9 ± 6.8
Post	53.2 ± 17.7	28.4 ± 16.8*	24.5 ± 13.3*	26.3 ± 6.9*
V ₀ (ml g⁻¹)	0.058 ± 0.012	0.041 ± 0.037	0.066 ± 0.042	0.077 ± 0.036
mLVV (ml g⁻¹)	0.137 ± 0.012	0.141 ± 0.037	0.167 ± 0.042	0.178 ± 0.036
ESP_mLVV (mmHg)
Pre	123.3 ± 9.6	120.1 ± 11.6	115.5 ± 16.4	112.5 ± 14.6
Post	116.2 ± 12.6	85.8 ± 13.7*^$	112.1 ± 20.9^#	117.4 ± 8.6^#
PVA_mLVV (mmHg ml beat⁻¹ g⁻¹)
Pre	7.81 ± 2.50	8.48 ± 1.47	7.88 ± 1.88	7.73 ± 1.45
Post	7.46 ± 0.87	5.06 ± 1.06*^$	7.43 ± 1.61^#	7.56 ± 0.47^#

End-systolic pressure–volume relationship (ESPVR) curve was obtained by the formula LVP = A{1 − exp[−B(LVV − V ₀)]}, where A and B are fitted parameters and V ₀ is LV volume intercept (=systolic unstressed volume) (11, 15, 17, 25), mLVV is midrange LV volume, ESP_mLVV is end-systolic pressure at mLVV. Systolic pressure–volume area (PVA) was obtained by the formula PVA = A(LVV − V₀) − A{1 − exp[−B (LVV − V ₀)]}/B (11, 15, 17, 25), where PVA_mLVV is PVA at mLVV. Values are mean ± SD. The sample number of SNJ + mI-R was about three times higher than the other groups because this was the most important group to evaluate the effect of SNJ on mI-R
Pre baseline data, Post 120 min after baseline data
* P < 0.05 versus time control
^# P < 0.05 versus mI-R
^$ P < 0.05 versus Pre

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