A new calpain inhibitor protects left ventricular dysfunction induced by mild ischemia-reperfusion in in situ rat hearts

Table 2 Hemodynamics in time control, mI-R, SNJ + mI-R, and SNJ groups

	Time control (n = 5)	mI-R (n = 6)	SNJ + mI-R (n = 15)	SNJ (n = 5)
ESV (ml)
Pre	0.062 ± 0.019	0.053 ± 0.024	0.070 ± 0.022	0.078 ± 0.012
Post	0.083 ± 0.042	0.117 ± 0.042	0.116 ± 0.037	0.086 ± 0.017
EDV (ml)
Pre	0.161 ± 0.040	0.158 ± 0.039	0.165 ± 0.027	0.170 ± 0.025
Post	0.177 ± 0.059	0.209 ± 0.052	0.206 ± 0.041	0.179 ± 0.033
SV (ml)
Pre	0.098 ± 0.022	0.105 ± 0.019	0.095 ± 0.019	0.092 ± 0.019
Post	0.094 ± 0.021	0.091 ± 0.026	0.090 ± 0.016	0.094 ± 0.016
ESV (ml g⁻¹)
Pre	0.085 ± 0.021	0.081 ± 0.038	0.104 ± 0.036	0.116 ± 0.037
Post	0.113 ± 0.054	0.180 ± 0.071	0.172 ± 0.057	0.125 ± 0.034
EDV (ml g⁻¹)
Pre	0.219 ± 0.042	0.238 ± 0.055	0.245 ± 0.039	0.253 ± 0.071
Post	0.241 ± 0.072	0.318 ± 0.089	0.306 ± 0.061	0.261 ± 0.069
SV (ml g⁻¹)
Pre	0.134 ± 0.023	0.157 ± 0.022	0.140 ± 0.023	0.136 ± 0.039
Post	0.128 ± 0.025	0.138 ± 0.039	0.134 ± 0.024	0.136 ± 0.035
ESP_ESV (mmHg)
Pre	89.7 ± 10.3	90.4 ± 11.3	86.9 ± 9.5	86.5 ± 6.2
Post	88.5 ± 6.4	71.4 ± 10.9*	85.3 ± 12.1	86.9 ± 4.2
Ea (mmHg ml⁻¹ g⁻¹)
Pre	681 ± 116	584 ± 105	642 ± 161	686 ± 237
Post	712 ± 149	551 ± 176	651 ± 132	669 ± 159
HR (beats min⁻¹)
Pre	330 ± 21	354 ± 29	369 ± 33	360 ± 30
Post	316 ± 31	342 ± 29	336 ± 38	348 ± 39

To compare volume data among different size of hearts, normalization by LVW is dispensable. Values are mean ± SD. The sample number of SNJ + mI-R was about three times higher than the other groups because this was the most important group to evaluate the effect of SNJ on mI-R
Pre baseline data, Post 120 min after baseline data, mI-R mild ischemic-reperfusion, ESV (ml) absolute end-systolic volume, EDV (ml) absolute end-diastolic volume, SV (ml) absolute stroke volume, ESV EDV and SV (ml g ⁻¹) each volume normalized by LVW, ESP _ESV end-systolic pressure, Ea effective arterial elastance (=ESP_ESV SV⁻¹), HR heart rate
* P < 0.05 versus Pre

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