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Table 1 Effects of compound C (CC) on reduced-to-oxidized glutathione ratio (GSH/GSSG) and thiobarbituric acid-reactive substances (TBARS) levels in control and postconditioned hearts

From: Effects of the AMP-activated protein kinase inhibitor compound C on the postconditioned rat heart

 

Pre-ischemic

Ischemic

Reperfusion

C

IPOC

C + CC

IPOC + CC

GSH/GSSG

14.58 ± 3.49

12.76 ± 1.77

7.92 ± 1.70*

17.69 ± 4.64+

8.41 ± 2.30*

10.39 ± 1.23

TBARS (nmol/gww)

7.70 ± 1.09

9.72 ± 1.23

20.73 ± 2.10**

12.12 ± 2.51++

23.49 ± 2.96**

20.71 ± 3.8**

  1. Data are the mean ± SEM (n = 8). Pre-ischemic, at the end of the 25 min equilibration period; ischemic, at the end of the 25 min ischemic period; reperfusion, at the end of the 30 min reperfusion period. Ischemic postconditioning was induced by six cycles of 10-s reperfusion interspersed by 10-s no-flow ischemia immediately after sustained ischemia. CC (10 μM) was added to the perfusion medium during the first 5 min of reperfusion
  2. C control hearts, IPOC postconditioned hearts
  3. * p < 0.05 versus pre-ischemic and ischemic hearts
  4. ** p < 0.01 versus pre-ischemic and ischemic hearts
  5. + p < 0.05 versus C reperfusion, C + CC reperfusion and IPOC + CC reperfusion
  6. ++ p < 0.01 versus C reperfusion, C + CC reperfusion and IPOC + CC reperfusion
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The Journal of Physiological Sciences

ISSN: 1880-6562

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