Fig. 19

Left-hand diagram differential percent changes in activity of cardiac (CSNA) and renal (RSNA) sympathetic innervation (means with standard errors) induced in conscious sheep by intracerebroventricular infusion of 0.6 M NaCl for 20 min (ICV NaCl). CSNA and RSNA were recorded separately in two groups of animals. Right-hand diagram indicated are hypothalamic lamina terminalis (LT, with partial absence of a blood–brain barrier) as common target for systemic AngII and Na⁺ and paraventricular nucleus (PVN) as common site of signal integration. Mediation of preoptic/anterior hypothalamic Na⁺-(or osmo-) receptor signals by the central angiotensinergic system would explain similarities of the central effects of elevated Na⁺ and of ANGII (Fig. 18) on efferent sympathetic control and their mutual reinforcement. Source of diagrams: May et al. [50]