Fig. 5

Effect of AVP receptor antagonists and anti-VEGF antibody on VEGF-induced a hyperplasia, b hypertrophy, and c type IV collagen production in rat mesangial cells. Cells were incubated with VEGF (100 ng/ml) and either YM218 (1 μM), SR 121463A (1 μM), or anti-VEGF antibody (10 μg/ml) for 72 h. Values are expressed as the mean ± SE of four independent experiments. *P < 0.05 versus control, ^# P < 0.05 versus VEGF