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Fig. 7 | The Journal of Physiological Sciences

Fig. 7

From: A stable ATP binding to the nucleotide binding domain is important for reliable gating cycle in an ABC transporter CFTR

Fig. 7

Comparison of a “kiss and run” hypothesis and b “stay and stray” hypothesis using a Monte Carlo computer simulation. a Gating kinetic model for each hypothesis. Kinetic parameters are shown in Tables 1 and 2, respectively. b Representative reproduced macroscopic current relaxations mimicking those in Y1219G (red), Y1219I (green), Y1219F (cyan) and Y1219W (blue). c Summary of the kinetics of the reproduced current relaxation. Mean ± SEM obtained from 10 reproduced current relaxations with different random number seeds are shown

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