Fig. 4
Effects of P-ATP on Y1219I mutant. a A representative macroscopic current trace of Y1219I-CFTR responding to rapid application and removal of 5 mM ATP or 100 μM P-ATP. Similar observations were made in nine membrane patches. b Effects of a brief rapid application of P-ATP on Y1219I macroscopic current during the slow phase of the current relaxation after ATP wash-out. A representative current trace from five similar experimental results is shown