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Table 2 Subjects’ exercise responses

From: Exertional dyspnea-related acidotic and sympathetic responses in patients with sequelae of pulmonary tuberculosis

 

Control subjects (n = 9)

TBsq patients (n = 49)

Rest

Peak

Rest

Peak

\( \dot{V} {\text{O}}_{2} \) (mL kg−1 min−1)

4.1 ± 0.3

28.2 ± 1.5

5.0 ± 0.2*

16.1 ± 0.7§

\( \dot{V} {\text{O}}_{2} \) (% predicted)

 

104.4 ± 7.7

 

58.3 ± 2.2§

Dyspnea (borg scale)

0.1 ± 0.1

7.8 ± 0.3

0.1 ± 0.1

8.5 ± 0.2

HR (beats min−1)

81 ± 3

144 ± 5

92 ± 2*

128 ± 3*

\( \dot{V} {\text{O}}_{2} \)/HR (mL beats−1)

2.7 ± 0.2

10.4 ± 0.6

2.8 ± 0.1

6.4 ± 0.3

f (beats min−1)

22 ± 2

34 ± 2

27 ± 1

39 ± 1

VT (mL)

577 ± 60

1611 ± 160

517 ± 16

829 ± 37§

\( \dot{V}_{\text{E}} \) (L min−1)

12.2 ± 0.7

54.3 ± 4.6

13.2 ± 0.4

31.3 ± 1.4§

VD/VT-ratio

0.40 ± 0.03

0.22 ± 0.01

0.39 ± 0.01

0.32 ± 0.01

pH

7.420 ± 0.005

7.358 ± 0.009

7.407 ± 0.004

7.335 ± 0.006

PaO2 (mmHg)

97.4 ± 3.1

84.3 ± 2.7

84.4 ± 1.7

58.6 ± 1.5§

PaCO2 (mmHg)

36.5 ± 0.8

38.1 ± 0.9

43.2 ± 0.9

49.8 ± 1.1§

LT (mg dl−1)

10.1 ± 1.3

43.8 ± 5.5

10.7 ± 0.6

25.9 ± 1.5

NE (ng mL−1)

0.4 ± 0.0

2.3 ± 0.5

0.9 ± 0.1

3.5 ± 0.3*

  1. Values are mean ± standard error of the mean
  2. TBsq sequelae of pulmonary tuberculosis, \( \dot{V} {\text{O}}_{2} \) oxygen uptake, HR heart rate, f breathing frequency,V T tidal volume, \( \dot{V}_{\text{E}} \) minute ventilation, V D /V T physiologic dead space/tidal volume ratio, PaO 2 arterial oxygen tension, PaCO 2 arterial carbon dioxide tension, LT plasma lactate level, NE plasma norepinephrine level
  3. * p < 0.05, p < 0.01, p < 0.001, § p < 0.0001 versus control subjects during each exercise phase