Fig. 12
From: Ca2+ regulation of endocochlear potential in marginal cells
a Possible mechanisms of the regulation in ENaCs and tight junctions (TJs) by increase in [Ca2+]c in marginal cells. b Electrical circuit model in the stria vascularis. In this model, we propose the electrical shunt pathway through marginal cells, and we do not need to consider the negative potential of hair cells, as was proposed previously [9]. Negative EP should be analyzed under the consideration of shunt resistance in the ESC in the future. EP was almost determined by the shunt resistance, because EPÂ ~Â EM if the R 2 is much larger than R 1 or R 3. We considered that EM is mainly produced by Na+ diffusion potential across the basolateral membrane of marginal cells