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Fig. 9 | The Journal of Physiological Sciences

Fig. 9

From: Factors affecting SOCE activation in mammalian skeletal muscle fibers

Fig. 9

Schematic diagram of the interrelationships among acute Ca2+ depletion of the SR, opening of the SOCE, Ca2+ uptake and release from the mitochondrial compartment and Ca2+ entry through the reverse plasma membrane Na+/Ca2+ exchange. 1 SR Ca2+ depletion procedure. 2 Ca2+ entry through SOC and Na+ entry by an unidentified pathway. 3 Ca2+ uptake into the mitochondria through its uniporter following the electrochemical gradient. 4 An unknown step linking mitochondria, SOCE and SR-Ca2+ content. 5 Ca2+ entry through the electrogenic plasma membrane Na+/Ca2+ exchange and 6 Ca2+ release from the mitochondria through its electroneutral Na+/Ca2+ exchange as a consequence of the rise in [Na+]i (see text for explanation)

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