Fig. 9From: Factors affecting SOCE activation in mammalian skeletal muscle fibersSchematic diagram of the interrelationships among acute Ca2+ depletion of the SR, opening of the SOCE, Ca2+ uptake and release from the mitochondrial compartment and Ca2+ entry through the reverse plasma membrane Na+/Ca2+ exchange. 1 SR Ca2+ depletion procedure. 2 Ca2+ entry through SOC and Na+ entry by an unidentified pathway. 3 Ca2+ uptake into the mitochondria through its uniporter following the electrochemical gradient. 4 An unknown step linking mitochondria, SOCE and SR-Ca2+ content. 5 Ca2+ entry through the electrogenic plasma membrane Na+/Ca2+ exchange and 6 Ca2+ release from the mitochondria through its electroneutral Na+/Ca2+ exchange as a consequence of the rise in [Na+]i (see text for explanation)Back to article page