Fig. 2
From: Factors affecting SOCE activation in mammalian skeletal muscle fibers
Two modalities of SOCE activation. Following depletion of the SR Ca2+ stores, achieved in the absence of external Ca2+, exposing the fibers to a solution containing 5 mM Ca2+, causes an increase in the [Ca2+]myo that basically follows two different modalities. Trace in a shows an experiment in which [Ca2+]myo, after a slow start, increases rapidly to a value higher than 500 nM, rendering it necessary to reverse it to avoid fiber contracture and damage, mode 1. Trace in b shows that in another fiber, the [Ca2+]myo increase is slower and saturates at a lower value, mode 2. The characteristics parameters of the two modes are resumed in Table 1. Notice the recovery of the responses to K+ and 4-CmC at the end of the runs