| | MAP (mmHg) | HR (beats/min) |
|---|
Low-salt SD |
Control | 89 ± 5 | 364 ± 22 |
SMTC | 85 ± 6 | 373 ± 19 |
SMTC+losartan | 69 ± 5* | 445 ± 26* |
High-salt SD |
Control | 101 ± 4 | 391 ± 15 |
SMTC | 109 ± 3 | 384 ± 11 |
SMTC+losartan | 102 ± 6 | 387 ± 14 |
CHF-DSS |
Control | 172 ± 8†,††
| 378 ± 20 |
SMTC | 198 ± 8* | 345 ± 18 |
SMTC+losartan | 157 ± 10 | 416 ± 12 |
- Control: before injection of drugs, SMTC: 40 min after a bolus injection of SMTC (10 mg/kg), SMTC+losartan: 60 min after subsequent injection of losartan (10 mg/kg) following SMTC
- Low-salt SD: five Sprague–Dawley (SD) rats fed a low-salt chow, high-salt SD: five SD rats fed a high-salt chow, CHF-DSS: five Dahl salt-sensitive rats with hypertensive heart failure induced by high-salt loading
- * Fisher’s PLSD P < 0.05 versus Control
- † Fisher’s PLSD P < 0.001 versus high-salt SD
- †† Fisher’s PLSD P < 0.001 versus low-salt SD
