The opposite roles of nNOS in cardiac ischemia–reperfusion-induced injury and in ischemia preconditioning-induced cardioprotection in mice

Table 1 Mouse body weight, heart weight, and hemodynamic data

Groups	Body weight (g)	Heart weight (mg)	Heart Rate (beats/min)		SBP (mmHg)		DBP (mmHg)		n
Groups	Body weight (g)	Heart weight (mg)	Pre	Post	Pre	Post	Pre	Post	n
WT Sham	30.5 ± 0.7	155.4 ± 3.8	579 ± 53	539 ± 35	113 ± 5	110 ± 11	74 ± 7	70 ± 5	10
WT IR	31.4 ± 0.9	157.3 ± 6.8	613 ± 37	559 ± 63	108 ± 7	109 ± 8	77 ± 6	78 ± 5	14
WT IR + L-VNIO	28.9 ± 0.8	148.7 ± 7.5	578 ± 45	614 ± 56	114 ± 7	108 ± 8	70 ± 7	78 ± 10	13
WT IR + MnTBAP	30.2 ± 0.7	154.8 ± 8.3	543 ± 63	573 ± 47	102 ± 7	104 ± 8	78 ± 7	75 ± 4	12
KO Sham	28.3 ± 0.9*	133.6 ± 7.3*	567 ± 38	587 ± 46	116 ± 12	107 ± 10	76 ± 9	71 ± 5	10
KO IR	27.7 ± 0.8*	129.6 ± 7.6*	578 ± 54	534 ± 71	118 ± 7	105 ± 9	78 ± 9	73 ± 9	10
KO IR + MnTBAP	28.2 ± 0.5*	132.4 ± 6.3*	591 ± 43	553 ± 35	109 ± 4	106 ± 10	75 ± 5	70 ± 3	10
WT IP	29.8 ± 0.6	150.5 ± 4.7	584 ± 56	593 ± 37	109 ± 8	100 ± 7	68 ± 9	71 ± 7	10
WT IP + L-VNIO	31.6 ± 1.1	149.9 ± 6.5	561 ± 48	578 ± 53	107 ± 6	115 ± 9	74 ± 6	76 ± 3	11
KO IP	27.1 ± 0.5*	133.5 ± 6.4*	538 ± 36	526 ± 54	113 ± 6	107 ± 7	78 ± 8	72 ± 9	10

Data are mean ± SEM. Measurements of heart rate, blood systolic blood pressure (SBP) and diastolic blood pressure (DBP) were performed under conscious conditions before (Pre) IR (ischemic reperfusion) or IP (ischemic preconditioning) and 24 h after (Post) recovery
WT wild type mice, KO nNOS knock out mice
* P < 0.05 compared with WT Sham group

ISSN: 1880-6562