Fig. 6

Effects of pharmacologic inhibition of nNOS by L-VNIO and genetic deletion of nNOS on IP-induced reduction of TBARS and nitrotyrosine levels. a Cardiac tissue TBARS levels were measured as described in “Methods” and results are expressed as mean ± SEM. Cardiac nitrotyrosine levels were determined as described in “Methods”. b The upper band is β-actin; lower bands for nitrotyrosine were shown for each group as described in “Methods”. c Results were normalized to multiples of the result for the WT Sham group, and are expressed as mean ± SEM. White bars represent WT mice groups; black bars represent KO groups. ¶P < 0.05 compared with the WT IR group, †P < 0.05 compared with the WT IP group