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Table 1 Steady-state activation (SSA) and inactivation (SSI) data for I Na in the heterologously expressed cardiac Nav1.5 (α) without or with its auxiliary β subunits

From: Late Na+ current produced by human cardiac Na+ channel isoform Nav1.5 is modulated by its β1 subunit

Conditions

SSI data

SSA data

V 1/2A (mV)

K A (mV)

n

V 1/2G (mV)

K G (mV)

n

α alone

−88.2 ± 0.9

−6.2 ± 0.2

11

−35.4 ± 1.2

5.5 ± 0.2

11

α + β1 + GFP

−85.1 ± 1.1*

−5.7 ± 0.4

13

−36.1 ± 2.1

6.4 ± 0.4

11

α + β1 (1:5)

−81.8 ± 0.9*

−5.8 ± 0.4

12

−34.7 ± 1.2

5.9 ± 0.2

7

α + β2 + GFP

−88.3 ± 1.8

−6.1 ± 0.4

9

−36.8 ± 1.2

5.9 ± 0.3

5

  1. SSA and SSI data were obtained from I Na data fit to Eqs. 1 and 2 (“Methods”), respectively. Data represent means ± SE, n stands for the cell number
  2. *P < 0.05 versus α alone. Statistically significant differences between results within the experimental groups were evaluated by ANOVA followed by Bonferroni’s post hoc test and were considered significant at P < 0.05
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The Journal of Physiological Sciences

ISSN: 1880-6562

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