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Table 1 Steady-state activation (SSA) and inactivation (SSI) data for I Na in the heterologously expressed cardiac Nav1.5 (α) without or with its auxiliary β subunits

From: Late Na+ current produced by human cardiac Na+ channel isoform Nav1.5 is modulated by its β1 subunit

Conditions SSI data SSA data
V 1/2A (mV) K A (mV) n V 1/2G (mV) K G (mV) n
α alone −88.2 ± 0.9 −6.2 ± 0.2 11 −35.4 ± 1.2 5.5 ± 0.2 11
α + β1 + GFP −85.1 ± 1.1* −5.7 ± 0.4 13 −36.1 ± 2.1 6.4 ± 0.4 11
α + β1 (1:5) −81.8 ± 0.9* −5.8 ± 0.4 12 −34.7 ± 1.2 5.9 ± 0.2 7
α + β2 + GFP −88.3 ± 1.8 −6.1 ± 0.4 9 −36.8 ± 1.2 5.9 ± 0.3 5
  1. SSA and SSI data were obtained from I Na data fit to Eqs. 1 and 2 (“Methods”), respectively. Data represent means ± SE, n stands for the cell number
  2. *P < 0.05 versus α alone. Statistically significant differences between results within the experimental groups were evaluated by ANOVA followed by Bonferroni’s post hoc test and were considered significant at P < 0.05