Fig. 2
From: Late Na+ current produced by human cardiac Na+ channel isoform Nav1.5 is modulated by its β1 subunit
Experimental approach used to elucidate I NaL of heterologously expressed Nav1.5. a, b Typical examples of the I Na currents recorded in tsA201 cells transiently transfected by α + β1-GFP. Shown are averaged traces from 50 sweeps before and after TTX (25 μM) application to assess “zero” current. c Difference I NaL current obtained by subtraction of “zero” current. Note different currents and time scales in a, b, and c to demonstrate peak (I NaT) and I NaL. V h = −120 mV, V m = −30 mV, 23°C