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Fig. 5 | The Journal of Physiological Sciences

Fig. 5

From: Reduced volume-regulated outwardly rectifying anion channel activity in ventricular myocyte of type 1 diabetic mice

Fig. 5

Effects of insulin on VRAC currents in ventricular myocytes from STZ-diabetic mice. a recordings of whole cell currents in myocytes from STZ-diabetic mice, obtained after ~6 h exposure to 100 nM insulin. Currents were recorded in isotonic (a, ISO) and hypotonic (b, HYPO) solutions with the same voltage steps as in Fig. 3d, and c shows their I–V relationships. b Magnitude of VRAC currents at +100 mV observed in the cells derived from normal (Normal) and STZ-diabetic mice (STZ) with and without insulin treatment. The cells were incubated at 37°C for 5–8 h, in the modified Tyrode solution without (Control) or with 100 nM insulin. *Significantly larger than control with P < 0.05, according to one-way ANOVA with post-hoc test. Number in parentheses indicates number of cells examined

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