Fig. 2

Hypotonicity-induced swelling of ventricular myocyte from normal and STZ-diabetic mice. a and b, time course of change of the relative cell area observed in the myocytes of normal (a) and STZ-diabetic (b) mice exposed to hypotonic (HYPO) solutions. The cells were initially bathed in isotonic solution, and then hypotonic (HYPO) solution was applied during the period indicated by bar. The values are expressed as relative to those obtained before application of hypotonic solution. c Shows an expanded illustration of a part of a (filled circle) and b (filled square). The values are expressed as relative to those obtained 5 min after application of hypotonic solution. *Significantly larger than the time-matched control data with P < 0.05 according to an unpaired t-test. A comparison of curves with repeated measures ANOVA yielded P < 0.01 (¶¶)