Table 2 Comparison of the single-channel properties between the mitochondrial VDAC and the maxi-anion channel

P_Cl/P_K (100/1,000 mM KCl)

1.7–1.9 [173, 174]

13.5 ± 2.3 [14]

P_acetate/P_Cl

0.41 [178]

0.58 ± 0.01 [14]

P_glutamate/P_Cl

0.4 [175]

0.17 [108]; 0.23 [14]

[Cl⁻] dependence for single-channel conductance

Linear up to 10 nS with no saturation [173]

Saturates at 580–640 pS with Kd = 77–120 mM [24, 104, 113]

Pore size

1 and 2 nm for different entrances [179, 180]

1.16 and 1.42 nm for different entrances [11]

Voltage-dependent “closed” state

Retains ~40% of initial conductance [150]

Non-conductive [8, 14]