Maxi-anion channel activities in VDAC-deficient fibroblasts. a, b, and c The channel activities in the cells derived from VDAC1-, VDAC2-, and VDAC3-knockout (vdac1
−/−, and vdac3
−/−) mice, respectively. d The channel activity in the cells derived from VDAC1/VDAC3 double-knockout mice with the vdac2 gene silenced by RNA interference. Left panels The representative current traces recorded at ±25 mV. Right panels The respective single-channel current-to-voltage (I–V) relationships. Each symbol represents the mean ± SEM (vertical bar) (n = 5–17). Modified from Sabirov et al.