Pharmacological profile of the maxi-anion channel in primary cultured neonatal rat cardiomyocytes. a Single-channel current traces recorded from excised outside-out (for Gd3+) and inside-out (for others) patches during application of step pulses (the protocol shown at the top of traces) in the absence (control) or presence of drugs. b Effects of drugs on mean currents recorded from excised macro-patches. Currents were recorded at +25 mV (open columns) and −25 mV (hatched columns). Data are normalized to the mean current measured before application of drugs and after correction for the background current. Each column represents the mean ± SEM (vertical bar). *P < 0.02 versus control. Modified from Dutta et al.