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Fig. 10 | The Journal of Physiological Sciences

Fig. 10

From: The maxi-anion channel: a classical channel playing novel roles through an unidentified molecular entity

Fig. 10

Maxi-anion channel is activated by osmotic swelling, ischemia and hypoxia, and its pore serves as the conducting pathways not only for a small inorganic anion, Cl, but also for negatively charged signaling molecules, ATP and glutamate. Transport of Cl defines the conventional roles of the maxi-anion channel in fluid secretion/absorption, in cell volume regulation, and in controlling the membrane potential. On the other hand, the wide nano-sized pore of the maxi-anion channel is capable to release extracellular signals, ATP and glutamate, from a cell, thus defining novel roles of this channel in stress-sensory signal transduction. See text for details

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