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Table 1 Effect of aging on two-dimensional muscle fiber and endplate structures

From: Age-related changes in two- and three-dimensional morphology of type-identified endplates in the rat diaphragm

2-D

Age (month)

Muscle fiber type

I

IIa

IIx/b

Endplate area (μm2)

2

238 ± 62

314 ± 64

384 ± 77a

10

378 ± 90

496 ± 130

790 ± 145a,b

24

327 ± 94

457 ± 122

741 ± 218a,b

30

284 ± 83

434 ± 160

780 ± 240b

Endplate surrounding area (μm2)

2

321 ± 95

439 ± 115

543 ± 132a

10

588 ± 195

800 ± 300

1,435 ± 358a,b

24

529 ± 157

784 ± 234

1,344 ± 411a,b

30

462 ± 142

779 ± 281

1,475 ± 493a,b

Endplate density (%)

2

74.1 ± 7.7

71.5 ± 7.5

70.7 ± 8.5

10

64.3 ± 11.0

62.0 ± 11.8

55.1 ± 5.6

24

61.8 ± 8.0

58.3 ± 7.3

55.1 ± 7.1

30

61.5 ± 7.5

55.7 ± 7.4

52.9 ± 5.1b

Muscle fiber diameter (μm)

2

21.1 ± 2.9

30.3 ± 2.8a

39.1 ± 3.5a

10

25.2 ± 3.2

34.5 ± 3.1a

51.3 ± 7.4a

24

23.4 ± 3.2

33.6 ± 3.4a

47.6 ± 7.3a

30

21.3 ± 4.0

33.2 ± 3.3a

51.3 ± 6.5a,b

Normalized endplate area (μm2/μm)

2

11.3 ± 2.6

10.4 ± 2.0

9.8 ± 1.7

10

15.0 ± 3.6

14.4 ± 4.7

15.4 ± 3.3b

24

14.0 ± 3.4

13.6 ± 3.0

15.6 ± 3.2b

30

13.3 ± 2.8

13.1 ± 3.3

15.2 ± 2.6b

  1. Values are means ± standard deviation
  2. aSignificant difference (P < 0.05) vs. type I
  3. bSignificant difference (P < 0.05) vs. 2-month-old group